Path of Exile 2: The Slithering Dead Quest – A Comprehensive Guide
This guide covers the "Slithering Dead" side quest in Path of Exile 2, detailing its walkthrough and offering advice on choosing the optimal rewards. This quest, initiated by Servi in the Ziggurat Encampment, involves uncovering the secrets of a rival tribe and the fate of her son.
The Slithering Dead Quest Walkthrough
- Locate the Venom Crypts: Access the Jungle Ruins map in Act 3 (and Act 3 Cruel). The Venom Crypts entrance is situated near the Jungle Ruins Waypoint. Note that this is a side path and not crucial to the main storyline. You can revisit it later if missed.

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Explore the Venom Crypts: Navigate the Venom Crypts until you find a corpse within the Den of the Serpent Priestess. The location of this corpse is randomized within the map.
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Retrieve the Venom: Interact with the corpse to obtain the Corpse-Snake Venom.
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Return to Servi: Teleport back to the Ziggurat Encampment and deliver the Venom to Servi to complete the quest.

Choosing the Right Venom Draught Reward
The Slithering Dead is a repeatable quest, appearing in Act 3 and Act 3 Cruel (Act 6). The rewards differ each time, making the choice crucial. Remember, your selection is permanent and cannot be changed.
Act 3 Rewards
Servi offers three Venom Draughts:
- Venom Draught of Stone: 25% increased Stun Threshold.
- Venom Draught of the Veil: 30% increased Elemental Ailment Threshold.
- Venom Draught of Clarity: 25% increased Mana Regeneration Rate.
Recommendation: The Venom Draught of Clarity is generally the best option. Increased mana regeneration is beneficial for most builds, especially melee characters often facing mana issues. The Venom Draught of the Veil is a solid alternative for builds that don't struggle with mana, particularly those less susceptible to elemental ailments. The Venom Draught of Stone is the least desirable unless your build specifically needs increased stun threshold.

Act 3 Cruel (Act 6) Rewards
The Act 3 Cruel rewards also comprise three Venom Draughts:
- Venom Draught of the Lost: Grants +10% to Chaos Resistance.
- Venom Draught of the Sky: Grants +5 to All Attributes.
- Venom Draught of the Marshes: Grants 15% Reduced Slowing Potency of Debuffs on you.
Recommendation: The Venom Draught of the Lost (+10% Chaos Resistance) is the superior choice in most cases due to the rarity of Chaos Resistance on gear. The exception is builds utilizing Chaos Inoculation (CI), where the Venom Draught of the Sky (+5 to all Attributes) might be preferable.
By carefully following this guide and making informed choices, you can maximize your rewards from the Slithering Dead quest in Path of Exile 2.